| 摘要 |
<p>The present invention provides an oral controlled release dosage form of a prokinetic agent comprising mosapride or its pharmaceutically acceptable salts and release rate controlling pharmaceutically acceptable excipient. The said dosage form is useful for once-a-day therapy in humans and releases mosapride in a controlled manner so as to provide control over mosapride plasma levels, such that the ratio of peak plasma levels to the plasma levels at 24 hours after administration, and the mean residence time of mosapride, are within a desirable range for the once-a-day therapy. The present invention also provides a process for the preparation of said oral controlled release dosage form.</p> |
