| 摘要 |
<p>A method for producing a mixed crystal of disodium 5'-guanylate and disodium 5'-inosinate (I+G mixed crystal), which comprises adding an aqueous mixed solution of disodium 5'-guanylate and disodium 5'-inosinate and a hydrophilic organic solvent simultaneously to a crystallization vessel while maintaining the proportion of the hydrophilic organic solvent in the liquid phase in the crystallization vessel at a level of 30 to 70 vol %, to thereby precipitate an I+G mixed crystal; and the method for producing an I+G mixed crystal, which further comprises adding a 5'-IMP2Na crystal and/or an I+G mixed crystal as a seed crystal. The method allows the suppression of the by-production of the amorphous solid of 5'-GMP2Na affecting adversely the separation of the crystal, which results in the production with high productivity of the mixed crystal with almost no amorphous solid which exhibits good separation.</p> |
