C-TERMINUS PROTEIN OF HUMAN NUCLEOLAR PHOSPHOPROTEIN140(HNOPP140) AND THE GENE THEREOF

摘要

PURPOSE: Provided are C-terminus protein of human nucleolar phosphoprotein hNopp140(hNOPP140) specifically binding with doxorubicin and the gene thereof. The C-terminus protein of hNopp140 acts on anticancer mechanism of doxorubicin in a living body, reduces toxicity of doxorubicin, and increases anticancer activity. CONSTITUTION: The hNopp140(hNOPP140) characteristically binds with doxorubicin and has amino acid sequence represented by the SEQ ID NO:1. Its coding gene has nucleotide sequence represented by the SEQ ID NO:2.