发明名称 |
Automated chemical synthesis apparatus |
摘要 |
The disclosed synthesis system is based on the idea of designing a synthesis and treatment procedure, substrates and anchor groups which enable biomolecules to be simultaneously produced in an entirely automatic manner. By using a pipetting robot to dispense the reagents, the reaction column can be arranged in a format suitable for subsequent treatment. For a pipetting robot to carry out even water-sensitive or air-sensitive synthesis protocols, certain structural measures must be taken. The operation principle of the automated and the synthesis sequence are described below as an example of a possible solution. The automation can work with conventional substrates and reagents. Handling, however, is simplified by new, specially adapted substrates and anchor groups. A special, simultaneous purification and aliquot portioning process improves product quality and makes the device easier to use.
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申请公布号 |
US6518067(B1) |
申请公布日期 |
2003.02.11 |
申请号 |
US19990367120 |
申请日期 |
1999.11.30 |
申请人 |
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF);ABIMED ANALYSEN-TECHNIK GMBH;IMB INSTITUT FUER MOLEKULARE BIO TECHNOLOGIE E.V. |
发明人 |
FRANK RONALD;MATYSIAK STEFAN;SCHREUER OLAF;GAUSEPOHL HEINRICH;ROSENTHAL ANDRE |
分类号 |
C12M1/00;B01J19/00;C07B61/00;C07H21/00;C07H21/02;C07H21/04;C07K1/04;C40B40/06;C40B40/10;C40B50/14;C40B60/14;(IPC1-7):C07H21/02;C07H27/12;B32B27/04;B01J10/00;B01J8/00 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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