| 发明名称 |
Human DNA mismatch repair proteins |
| 摘要 |
The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a prodeudre for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
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| 申请公布号 |
US2003027177(A1) |
申请公布日期 |
2003.02.06 |
| 申请号 |
US20020079429 |
申请日期 |
2002.02.22 |
| 申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
HASELTINE WILLIAM A.;RUBEN STEVEN M.;WEI YING-FEI;ADAMS MARK D.;FLEISCHMANN ROBERT D.;FRASER CLAIRE M.;FULDNER REBECCA A.;KIRKNESS EWEN F.;ROSEN CRAIG A. |
| 分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K48/00;A61P35/00;C07K14/435;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12P21/08;C12Q1/68;C12R1/19;(IPC1-7):C12Q1/68;C07H21/04;C12N9/22;C12N5/06 |
主分类号 |
C12N15/09 |
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