| 摘要 |
<p>A facile means of diagnosing polycythemia vera is provided by detecting expression of the DLX7 gene in a sample of a hematopoietic cell from an individual. Increased expression of DLX7 may also be used to diagnose acute myeloid leukemia. A method is provided for treating patients suffering from polycythemia vera or acute myeloid leukemia using agents that inhibit or prevent expression of the DLX7 gene or that inhibit or prevent any downstream effects of DLX7 gene expression. Examples of the agents useful in this treatment are DLX7 antisense oligonucleotides and decoy therapy directed at binding the DLX7 gene product and preventing its contribution to the pathogenesis of polycythemia vera.</p> |
