S-nitrosothiols as agents for the treatment of circulatory dysfunctions

摘要

An S-nitrosothiol derivative of penicillamine or glutathione, or pharmaceutically acceptable salt thereof, having the general formula (I) wherein: A and B are phenyl groups or together form a bridging group -CH-Q-CH2- to complete a six-membered heterocyclic ring in which Q represents oxygen, sulphur or a group >N-R3 wherein R3 is a hydrogen atom or a C1-C4 alkyl group; R1 is an acyl group; and R2 is a hydroxyl group or -NHCH2COOH; with the proviso that if R1 is an aliphatic acyl group then R2 is a hydroxyl group; and if R1 is a glutamic acid residue bound via its non amino acid carboxyl then R2 is -NHCH2COOH.