发明名称 |
PHARMACEUTICAL FORMULATION COMPRISING A PROTON PUMP INHIBITOR AND ANTACIDS |
摘要 |
The present invention deals with a multiparticulate tablet, which disintegrates in the mouth containing: i) a proton pump inhibiting agent, in particular of the benzimidazole type, in the form of enteric coated microgranules, which enteric coated granules are overcoated with at least one barrier coating, such as for instance a methacrylic copolymer-based protective film; ii) at least one antacid in the form of granules, for instance based on CaCO3 and/or Mg(OH)2 and/or Al(OH)3; and, iii) a mixture of excipients comprising at least one disintegrating agent, one diluent agent, a lubricant, and optionally a swelling agent, a permeabilising agent, sweeteners, flavourings and colours. Furthermore, the present invention is directed to processes for the manufacture of the tablet and its use in the treatment of gastrointestinal disorders.
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申请公布号 |
WO03007917(A1) |
申请公布日期 |
2003.01.30 |
申请号 |
WO2002SE01370 |
申请日期 |
2002.07.10 |
申请人 |
ASTRAZENECA AB;CRIERE, BRUNO;NOURI, NOURREDINE;PILBRANT, AAKE;SUPLIE, PASCAL;ZUCCARELLI, JEAN-MARC |
发明人 |
CRIERE, BRUNO;NOURI, NOURREDINE;PILBRANT, AAKE;SUPLIE, PASCAL;ZUCCARELLI, JEAN-MARC |
分类号 |
A61K9/00;A61K9/16;A61K9/20;A61K9/26;A61K9/50;A61K31/4439;A61K33/06;A61K33/08;A61K33/10;A61K45/06;A61K47/02;A61K47/04;A61K47/10;A61K47/12;A61K47/14;A61K47/16;A61K47/20;A61K47/32;A61K47/38;A61K47/42;A61P1/04;(IPC1-7):A61K9/26;A61K31/443 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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