| 摘要 |
Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabiliz ed using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alk yl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least on e of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof , and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grap e seed or green tea extracts are employed in some embodiments.
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