| 摘要 |
Cells can be imaged, e.g., in vivo, in an animal or human subject by introducing into the cells a nucleic acid encoding an internalizing receptor, administering to the animal or human subject a reporter complex including one or more receptor-specific reporter moieties linked to one or more reporter groups, such as magnetic particles, and detecting the reporter complex, e.g., using magnetic resonance imaging, and thus detecting the cells. If a specific gene is expressed in a constant, known ratio compared to expression of the receptor, the expression of that gene can be monitored by detecting the reporter complex, and thus, concomitantly, expression of the internalizing receptor and the specific gene.
|
