TARGETING THROUGH INTEGRINS

摘要

The present invention relates to a gene delivery vehicle comprising a general nucleic acid binding domain and an integrin binding domain. Typically, the at least two different domains of the gene delivery vehicle are somehow linked. Said gene delivery vehicle may be used to deliver a therapeutic molecule to a cell exposing integrin, thereby at least in part enhancing the efficacy of gene delivery using integrin receptors. In one embodiment, an integrin binding domain of the invention is derived from the C-terminal region of the Yersinia pseudotuberculosis invasin or a functional homologue thereof.