发明名称 |
N,N-DINITRAMIDE SALTS AS SOLUBILIZING AGENTS FOR BIOLOGICALLY ACTIVE AGENTS |
摘要 |
A method is provided for enhancing the solubility of an ionizable compound i n a lipophilic medium by admixing the compound with an effective solubility- enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2 following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method i s useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compoun ds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.
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申请公布号 |
CA2453179(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
CA20022453179 |
申请日期 |
2002.07.09 |
申请人 |
SRI INTERNATIONAL |
发明人 |
BOTTARO, JEFFREY C.;PETRIE, MARK A.;PENWELL, PAUL E.;BOMBERGER, DAVID C. |
分类号 |
A01N25/02;A01N43/70;A01N59/00;A61K47/02;A61K47/04;A61K47/18;A61K47/22;A61K47/32;A61K47/48;A61K49/00;C07C211/32;C07D453/04;(IPC1-7):C07C243/00;C07C243/02;A61K31/16 |
主分类号 |
A01N25/02 |
代理机构 |
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