VEGFR-1 ANTIBODIES TO TREAT BREAST CANCER

摘要

The present invention is directed to methods of inhibiting tumor cells by administering an antagonist which inhibits the VEGF/VEGFR-1 autocrine loop o f tumor cells. Additional antagonists can be added to inhibit endothelial paracrine loop by inhibiting other VEGFRs expressed on endothelial cells, particularly VEGFR-2. Examples of antagonists include antibodies and small molecules. A preferred cancer for treatment is breast cancer.