发明名称 |
ANTI-NEOPLASTIC VIRAL AGENTS |
摘要 |
A viral DNA construct, and virus encoded thereby, is provided having one or more tumour specific transcription factor binding sites in place of one or more wild type transcription factor binding sites operatively positioned in the promoter region which controls expression of E1A open reading frame. Preferred constructs place the tumour specific transcription factor binding sites in operative relation to DNA polymerase, DNA terminal protein and/or D NA binding protein. Compositions and constructs contained therein are provided, particularly for use in therapy. Methods of treating patients for neoplasms are also provided.
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申请公布号 |
CA2453357(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
CA20022453357 |
申请日期 |
2002.07.12 |
申请人 |
BTG INTERNATIONAL LIMITED |
发明人 |
HOMICSKO, KRISZTIAN GYULA;FUERER, CHRISTOHPE;IGGO, RICHARD DEREK |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K48/00;A61P1/00;A61P1/16;A61P35/00;A61P35/04;C12N7/04;C12N15/34;C12N15/861;(IPC1-7):C12N15/86;C12N7/00;C07K14/075 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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