发明名称 |
METHODS AND DEVICES FOR IMMUNIZING A HOST THROUGH ADMINISTRATION OF NAKED POLYNUCLEOTIDES WHICH ENCODE ANTIGENIC PEPTIDES |
摘要 |
The invention is directed to methods for introducing biologically active peptides into a host by administration of polynucleotides which operatively encode for the peptide of interest. In a preferred embodiment of the invention, a mammal is desensitized to an antigen, in particular an allergen , through administration to the mammal of polynucleotides which operatively encode the antigen. The antigen-encoding polynucleotides are administered to host tissues which have a high concentration of antigen presenting cells in them relative to other host tissues. The method is particularly useful in treating allergies because the allergen-encoding polynucleotides of the invention to induce tolerance while suppressing IgE antibody formation. Devices and compositions for use in the methods of the invention are also described.
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申请公布号 |
CA2204253(C) |
申请公布日期 |
2003.01.21 |
申请号 |
CA19952204253 |
申请日期 |
1995.10.31 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARSON, DENNIS A.;RAZ, EYAL;HOWELL, MEREDITH L. |
分类号 |
C12N15/09;A61B17/20;A61K9/00;A61K9/08;A61K9/12;A61K31/70;A61K31/7088;A61K38/00;A61K38/22;A61K39/00;A61K39/35;A61K48/00;A61N1/30;A61P37/04;A61P43/00;C07K14/11;C07K14/495;C07K14/54;C07K14/55;C07K14/77;C07K16/00;C12N5/10;C12N15/12;C12N15/87;G01N33/50;G01N33/569;G01N33/68;(IPC1-7):A61K48/00;G01M5/00;G01N33/564 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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