发明名称 |
Process for preparing contrast agents |
摘要 |
The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substantially aggregate-free sterile aqueous dispersion of gas-containing vesicles.
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申请公布号 |
US6509004(B1) |
申请公布日期 |
2003.01.21 |
申请号 |
US20000506682 |
申请日期 |
2000.02.18 |
申请人 |
AMERSHAM HEALTH AS |
发明人 |
HENRIKSEN INGRID;KASPARKOVA VERA;ANDERSEN ARNFINN;FAHLVIK ANNE KJERSTI;ODEGARDSTUEN LIV INGRID |
分类号 |
A61K49/22;(IPC1-7):A61B8/00;B01F17/00 |
主分类号 |
A61K49/22 |
代理机构 |
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