发明名称 |
REVERSED MAMMALIAN PROTEIN-PROTEIN INTERACTION TRAP |
摘要 |
The present invention relates to a recombinant receptor, comprising a ligand-binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to said heterologous bait peptide, either in presence or absence of a ligand binding to said ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The present invention also relates to a method to screen compounds that disrupt compound-compound-binding using said recombinant receptor. |
申请公布号 |
WO03004643(A2) |
申请公布日期 |
2003.01.16 |
申请号 |
WO2002EP07419 |
申请日期 |
2002.07.02 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW;EYCKERMAN, SVEN;TAVERNIER, JAN;VANDEKERCKHOVE, JOEL |
发明人 |
EYCKERMAN, SVEN;TAVERNIER, JAN;VANDEKERCKHOVE, JOEL |
分类号 |
C07K14/47;C07K14/705;C12N15/10 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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