发明名称 |
Translation enhancer element of the human amyloid precursor protein gene |
摘要 |
The present invention is directed to a DNA element that enhances the translation of the human amyloid precursor protein (APP) gene. The enhancer may be incorporated into expression vectors to enhance recombinant protein production. In addition, the invention is directed to an assay that utilizes vectors containing the translation enhancer element for the purpose of identifying agents that modulate the expression of the human amyloid precursor protein. These agents will ultimately be used to suppress APP expression in patients with Alzheimer's disease.
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申请公布号 |
US2003013867(A1) |
申请公布日期 |
2003.01.16 |
申请号 |
US20010910757 |
申请日期 |
2001.07.24 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
ROGERS JACK |
分类号 |
C12N15/09;A61K48/00;C07K14/47;C12N1/15;C12N1/19;C12N5/10;C12N15/67;C12N15/85;C12P21/02;C12Q1/02;C12Q1/68;(IPC1-7):C07H21/04;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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