发明名称 |
Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (EGF-R); diagnostic and therapeutic use |
摘要 |
Humanized and chimeric monoclonal antibodies that recognize EGF-R and comprise an artificial sequence at least of the FRs of the heavy chain variable region of a human immunoglobulin. The humanized and monoclonal antibodies may comprise variable regions of non-human origin and constant regions of human origin with amino acid substitutions with the variable regions and/or framework regions. Use of the antibodies for therapeutical and diagnostic purposes is also disclosed.
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申请公布号 |
US6506883(B2) |
申请公布日期 |
2003.01.14 |
申请号 |
US19980217268 |
申请日期 |
1998.12.21 |
申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR |
发明人 |
METEO DE ACOSTA DEL RIO CHRISTINA MARIA;RODRIGUEZ ROLANDO PEREZ;FRIAS ERNESTO MORENO |
分类号 |
G01N33/566;A61K38/00;A61K38/18;A61K39/395;A61P35/00;C07H21/04;C07K14/485;C07K14/52;C07K14/705;C07K14/71;C07K16/00;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N5/12;C12N15/02;C12N15/09;C12P21/08;C12R1/91;G01N33/574;G01N33/577;(IPC1-7):G07K16/28 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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地址 |
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