METHOD AND SET FOR PERFORMING EXPRESS DIAGNOSIS STUDY OF CLINICALLY EXPRESSED IMMUNOLOGIC INSUFFICIENCY FORMS

摘要

FIELD: medicine. SUBSTANCE: method involves determining low avidity antibodies secretion growth in blood serum or secrets relative to normal level. Normal antibodies of G class of low avidity and/or specific to antigens of G class antibodies are transformed into high avidity ones in blood serum and/or lymph and/or secrets by exerting selective action upon intramolecular interdomain links by applying physical and/or chemical and/or biological factors to determine structural and/or functional and/or protective properties of antibodies and/or SH groups availability in IgG before and after applying the transforming action. Relations binding results obtained before and after low avidity antibody transformation are determined for each feature, respectively. Modulation index is calculated and interpreted in terms of immunologic insufficiency and its manifestation degree and/or immunologic insufficiency form as preclinical latent development one (LII-1 or LII-2) or clinically marked one (II-1 or II-2) and/or immunity stress and immune response efficiency in progress and antibody maturity process dysfunction in plasmatic cells. EFFECT: enhanced accuracy of diagnosis. 10 cl, 12 tbl