| 摘要 |
This invention relates to galanin and its uses. In particular, the invention provides a knockout mouse which lacks a functional galanin gene. The mouse may be used to investigate the effects of galanin. It has also been unexpectedly discovered that galanin antagonists may be used in the management of pain, particularly painful neuropathies, the suppression of pain, in the suppression of lactation, in the treatment of prolactinoma and in anaesthesia. Additionally, the use of galanin agonists may be used in the treatment of Alzheimer's disease, in improving memory and cognition and in the treatment of nerve damage, such as the promotion of nerve regeneration
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