| 摘要 |
PURPOSE: A biodegradable amphiphilic block copolymer having a polyethylenimine hydrophilic block and a polyester-based polymer hydrophobic block, a polymer assembly self-assembled in aqueous solution and its method using the copolymer are provided, wherein polymer assembly has a very critical micelle concentration of 10¬-3 g/L and can be applied for the solubilization of a hardly-soluble drug and the drug delivery system of proteins, genes and charged drugs. CONSTITUTION: The amphiphilic block copolymer comprises a polyethylenimine hydrophilic block and a biodegradable aliphatic polyester-based polymer hydrophobic block. Preferably the hydrophobic polymer is selected from the group consisting of poly-L-lactic acid, poly-D,L-lactic acid, poly-D-lactic acid-co-glycolic acid, poly-L-lactic acid-co-glycolic acid, poly-D,L-lactic acid-co-glycolic acid, poly-caprolactone, poly-valerolactone, poly-hydroxybutyrate, poly-hydroxyvalerate, poly-1,4-dioxan-2-on, and their mixtures. The average mass molecular weight of polyethylenimine is 100-10,000. The polymer assembly is prepared by dispersing the block copolymer into a solvent, and has an average particle size of 10-1,000 nm. |
