Macromolecular imaging agents comprising a polyalkylenimine dendrimer conjugated to a metal chelate are disclosed. In particular embodiment, the imaging agent is a diaminobutane-core polypropylenimine dendrimer having surface amino groups conjugated to gadolinium metal chelates. Administration of this gadolinium conjugate to a subject permits visualization of liver micrometastases as small as about 0.3mm in a magnetic resonance image of the subject's liver.
申请公布号
WO03001218(A2)
申请公布日期
2003.01.03
申请号
WO2002US20118
申请日期
2002.06.24
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;BRECHBIEL, MARTIN, W.;KOBAYASHI, HISATAKA