This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate <i>in vivo</i> delivery or targeting.
申请公布号
WO03000711(A1)
申请公布日期
2003.01.03
申请号
WO2002CA00944
申请日期
2002.06.25
申请人
THE UNIVERSITY OF BRITISH COLUMBIA;ANDERSEN, RAYMOND, J.;ROBERGE, MICHEL;BRITTON, ROBERT, A.;DE SILVA, E., DILIP
发明人
ANDERSEN, RAYMOND, J.;ROBERGE, MICHEL;BRITTON, ROBERT, A.;DE SILVA, E., DILIP