| 发明名称 |
1,2,4-TRIOXOLANE ANTIMALARIALS |
| 摘要 |
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
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| 申请公布号 |
WO03000676(A1) |
申请公布日期 |
2003.01.03 |
| 申请号 |
WO2002US19767 |
申请日期 |
2002.06.21 |
| 申请人 |
MEDICINES FOR MALARIA VENTURE;VENNERSTROM, JONATHAN, L.;CHOLLET, JACQUES;DONG, YUXIANG;MATILE, HUGUES;PADMANILAYAM, MANIYAN;TANG, YUANQING;CHARMAN, WILLIAM, N. |
发明人 |
VENNERSTROM, JONATHAN, L.;CHOLLET, JACQUES;DONG, YUXIANG;MATILE, HUGUES;PADMANILAYAM, MANIYAN;TANG, YUANQING;CHARMAN, WILLIAM, N. |
| 分类号 |
A61K31/335;A61K31/357;A61K31/382;A61K31/4035;A61K31/4178;A61K31/4196;A61K31/422;A61K31/427;A61K31/438;A61K31/444;A61K31/4709;A61K31/496;A61K31/497;A61K31/5377;A61P33/06;A61P33/12;A61P35/00;C07D323/02;C07D405/06;C07D405/12;C07D405/14;C07D413/10;C07D417/04;C07D417/06;C07D417/12;C07D491/10;C07D491/113;C07D493/10;C07D495/10;(IPC1-7):C07D323/02;C07D405/08;C07D419/08;C07D521/00 |
主分类号 |
A61K31/335 |
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