发明名称 |
Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (LAG-3) |
摘要 |
A method to prevent graft rejection of transplanted cells, tissues or organs without general immunosuppression is described. The method employs a newly discovered protein, LAG-3. When allogeneic or xenogeneic cells are engineered to express LAG-3 on their surface and transplanted, immune destruction of the implanted cell, tissue or organ is prevented, while the host's immune system remains functional. A particular application of this method allows the preparation of a universal gene therapy host cell expressing LAG-3 on its surface for protection from graft rejection by a host's immune system. |
申请公布号 |
US6500422(B2) |
申请公布日期 |
2002.12.31 |
申请号 |
US19990319147 |
申请日期 |
1999.12.01 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
BIFFONI MAURO;PAPOIAN RUBEN |
分类号 |
A01K67/027;A61K35/12;A61K38/00;A61K38/17;A61K38/19;A61K48/00;A61P37/02;C07K;C07K14/52;C07K14/705;C12N5/08;C12N5/10;C12N15/09;C12N15/11;C12N15/19;(IPC1-7):A61K48/00;C12N5/00;C12N15/63 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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