METHODS FOR CLONING MAMMALS USING REMODELING FACTORS
摘要
Methods and compositions are provided for remodeling nuclear donor material used in nuclear transfer procedures. By exposing donor chromatin to one or more exogenous remodeling factors, the limited ability of mammalian oocytes to remodel the chromatin of differentiated cells, including fetal and live-born somatic cells, can be increased, resulting in dramatically improved cloning efficiencies.
申请公布号
WO02103350(A1)
申请公布日期
2002.12.27
申请号
WO2002US19103
申请日期
2002.06.14
申请人
INFIGEN, INC.;LENO, GREGORY, H.;EILERTSEN, KENNETH;BETTHAUSER, JEFFREY, M.;FORSBERG, ERIK, J.
发明人
LENO, GREGORY, H.;EILERTSEN, KENNETH;BETTHAUSER, JEFFREY, M.;FORSBERG, ERIK, J.