FCE FUSION PROTEINS FOR TREATMENT OF ALLERGY AND ASTHMA

摘要

The present invention includes Fc epsilon fragments conjugated with FC gamma fragments, for example, Fc epsilon 1-Hinge-FcE2-FcE3-FcE4-FCy; Hinge-FcE2-FcE3-FcE4- Fcy; FC epsilon 2-Fc epsilon 3-Fc epsilon 4-FC gamma ; FC epsilon 2-Fc epsilon 3- Fc gamma ; FC epsilon 3-Fc gamma ; and FC epsilon 3-Fc epsilon 4-FC gamma , or any derivative or peptide, which has equivalent immunological function. The Fc gamma fragment may be a fragment of any of the IgG subclasses (lgG1 I IgG2, IgG3, or IgG4), preferably IgG1 or IgG3, wherein the fragment binds FcyRIIB. The present invention also includes compositions suitable for administering to a patient suffering from an allergic disease comprising the fusion protein construct in a pharmaceutical composition including, for example, an excipient, diluant, or carrier. This treatment may be combined with anti-IgE therapy or allergen immunotherapy.