ANTIBODIES THAT BLOCK RECEPTOR PROTEIN TYROSINE KINASE ACTIVATION, METHODS OF SCREENING FOR AND USES THEREOF

摘要

Molecules containing the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosi ne kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found throu gh screening methods, where a soluble dimeric form of a receptor protein tyrosi ne kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat o r inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.