Medicinal compositions

摘要

A pharmaceutical composition comprising a macrolide compound, such as tricyclic compound or its salt, a dissolution/absorption promoter, a pharmaceutical base, a compatibilising agent and a thickener, where: the tricyclic compound is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa -4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone or its hydrate; the dissolution/absorption promoter is diethyl sebacate; the pharmaceutical base is hydrophilic glycols; the compatibilising agent is diethylene glycol monoethyl ether; and the thickener is cellulose polymer or carboxyvinyl polymer The pharmaceutical composition comprising a macrolide compound is stable, has absorption kinetics properties and has a low irritation potential.