发明名称 |
Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof |
摘要 |
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
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申请公布号 |
US2002194628(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
US20010017718 |
申请日期 |
2001.12.14 |
申请人 |
WEISGRABER KARL H.;FARESE ROBERT V.;RAFFAI ROBERT;DONG LI-MING |
发明人 |
WEISGRABER KARL H.;FARESE ROBERT V.;RAFFAI ROBERT;DONG LI-MING |
分类号 |
C07K14/775;C12N5/02;C12N15/85;G01N33/68;G01N33/92;(IPC1-7):A01K67/00;A01K67/027;C12N5/06 |
主分类号 |
C07K14/775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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