发明名称 |
Methods and compositions for regulating protein-protein interactions |
摘要 |
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
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申请公布号 |
US6495376(B1) |
申请公布日期 |
2002.12.17 |
申请号 |
US19990252404 |
申请日期 |
1999.02.18 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
LU KUN PING;ZHOU XIAO ZHEN |
分类号 |
G01N33/50;A61K38/08;A61K38/10;A61K38/17;A61K38/52;A61K45/00;A61K47/48;A61P25/28;A61P35/00;C07K14/47;C12N5/06;C12N9/90;C12N9/99;G01N33/15;G01N33/566;(IPC1-7):G01N33/566 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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