| 摘要 |
PROBLEM TO BE SOLVED: To provide a neuraminic acid compound having an excellent sialidase inhibitory activity and effective as a medicine (especially a therapeutic agent or a prophylactic agent for influenza) by oral administration and its pharmacologically acceptable ester or salt. SOLUTION: This compound is represented by the general formula (1) [wherein, R<1> and R<2> are each hydrogen atom or hydroxy group; R<3> , R<4> , R<5> , R<6> , R<7> and R<8> are each hydrogen atom, an alkyl group or the like, R<9> is an alkyl group or the like; n is 1, 2 or 3; m is 0, 1 or 2; and R<10> and R<11> are each hydrogen atom, a group represented by the formula C(=O)OC(RG<1> )(RG<2> )OC(=O) RG<3> , a group represented by the formula C(=O)OC(RG<1> )(RG<2> )OC(=O)ORG<4> or a group represented by the formula C(=O)ORG<5> (wherein, RG<1> , RG<2> , RG<3> and RG<4> denote each hydrogen atom, an alkyl group or the like, except that both R<10> and R<11> are hydrogen atoms)] or its pharmacologically acceptable ester or salt. |
