| 发明名称 |
Methods of treatment involving human MDA-7 |
| 摘要 |
The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed to methods for treating a subject with an angiogenesis-related disease. In one embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells, is administered to said patient with an angiogenesis-related disease. The present invention thus provides for treatment of angiogenesis-related disease by through expression of mda-7 and inhibition angiogenesis. Such diseases include cancer. |
| 申请公布号 |
US2002183271(A1) |
申请公布日期 |
2002.12.05 |
| 申请号 |
US20010017472 |
申请日期 |
2001.12.07 |
| 申请人 |
CHADA SUNIL;GRIMM ELIZABETH;MHASHILKAR ABNER;RAMESH RAJAGOPAL |
发明人 |
CHADA SUNIL;GRIMM ELIZABETH;MHASHILKAR ABNER;RAMESH RAJAGOPAL |
| 分类号 |
C12N15/09;A61K31/513;A61K31/555;A61K31/65;A61K35/76;A61K38/00;A61K38/20;A61K39/00;A61K39/12;A61K45/00;A61K48/00;A61P1/04;A61P9/10;A61P17/06;A61P27/00;A61P27/06;A61P29/00;A61P35/00;A61P35/02;A61P35/04;A61P37/04;A61P43/00;(IPC1-7):A61K48/00;A61K38/43 |
主分类号 |
C12N15/09 |
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