S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy-nucleoside complexes as potent inhibitors of HIV-replication

摘要

Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3 @ -azido-2 @ ,3 @ -dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of human-immunodeficiency virus 1 & 2 in vitro and in vivo, particularly on the reverse transcriptase, and having a high therapeutic index.