发明名称 |
Model for von Hippel-Lindau disease |
摘要 |
Disclosed herein are nucleic acid molecules that can be used to effect a loss of function of the von Hippel-Lindau (VHL) allele in somatic and/or germ cells of a mammal and methods for using these molecules to create conditional VHL gene targeted and conditional VHL knockout animals. Disclosed herein are conditional VHL gene target vectors which, when inserted into an endogenous VHL gene, can result in deletion of an exon of a VHL gene by site-specific recombinaton when a recombinase is expressed conditionally.
|
申请公布号 |
USH2056(H1) |
申请公布日期 |
2002.12.03 |
申请号 |
US20010971476 |
申请日期 |
2001.10.04 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SCHMIDT LAURA S.;MA WENBIN;TESSAROLLO LINO;ZBAR BERTON |
分类号 |
C07K14/47;C12N15/85;(IPC1-7):C07H21/04;C12N9/00;C12N5/00 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|