发明名称 |
POLYNUCLEOTIDE ENCODING A NOVEL TRP CHANNEL FAMILY MEMBER, TRP-PLIK2, AND SPLICE VARIANTS THEREOF |
摘要 |
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP- PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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申请公布号 |
CA2447948(A1) |
申请公布日期 |
2002.11.28 |
申请号 |
CA20022447948 |
申请日期 |
2002.05.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHEN, JIAN;LEE, NING;BOL, DAVID;BLANAR, MICHAEL;WU, SHUJIAN;CHANG, HAN;LEE, LIANA;FEDER, JOHN |
分类号 |
C07K14/705;C12N15/12;(IPC1-7):C12N15/12;C12P21/00;A61K38/17;C07K16/28;G01N33/50;C12N15/63;C12Q1/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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