| 发明名称 |
MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES |
| 摘要 |
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl- piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptir activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
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| 申请公布号 |
CA2448080(A1) |
申请公布日期 |
2002.11.28 |
| 申请号 |
CA20022448080 |
申请日期 |
2002.05.21 |
| 申请人 |
NEUROGEN CORPORATION |
发明人 |
HUTCHISON, ALAN;PETERSON, JOHN;DOLLER, DARIO;SHEN, YIPING;BAKTHAVATCHALAM, RAJAGOPAL;YIN, HELEN;STEENSTRA, CHERYL;YOON, TAEYOUNG;DE SIMONE, ROBERT;PRINGLE, WALLACE;HE, XIAO-SHU;CALDWELL, TIMOTHY;GUSTAVSON, LINDA E. |
| 分类号 |
G01N33/53;A61K31/352;A61K31/451;A61K31/495;A61K31/496;A61K31/4985;A61K31/506;A61K31/551;A61P3/04;A61P3/10;A61P9/00;A61P15/00;A61P25/00;A61P43/00;C07D209/86;C07D211/44;C07D211/52;C07D213/64;C07D213/74;C07D215/12;C07D215/20;C07D223/04;C07D239/47;C07D243/08;C07D295/08;C07D295/096;C07D295/108;C07D295/18;C07D311/18;C07D311/58;C07D317/58;C07D401/12;C07D471/04;C07D487/04;C07D487/08;C07D513/04;G01N33/566;(IPC1-7):C07D213/74;C07D239/46 |
主分类号 |
G01N33/53 |
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