METHOD TO INDUCE NEOVASCULAR FORMATION AND TISSUE REGENERATION

摘要

The present invention refers to a method for inducing neovascular formation and tissue regeneration in mammals. The claimed method is characterized by the administration of a nucleotide sequence encoding for the active site of the vascular endothelial growth factor (VEGF). The method induces cell mitosis, myocardiogenesis, arteriogenesis, vasculogenesis and Iymphangiogenesis in mammalian tissues. The method employs a plasmid vector encoding the nucleotide sequence. The administration is performed by intramyocardial route.