39443, novel human gamma-butyrobetaine hydroxylase

摘要

The present invention relates to a newly identified human gamma-butyrobetaine hydroxylase (gamma-BBH). The invention also related to polynucleotides encoding the gamma-butyrobetaine hydroxylases. The invention further relates to methods using the gamma-BBH polypeptides and polynucleotides as a target for diagnosis and treatment in gamma-BBH-mediated or -related disorders. The invention further relates to drug-screening methods using the gamma-BBH polypetides and poly-nucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the gamma-BBH polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.