| 发明名称 |
A NON-MITOGENIC COMPETITIVE HGF ANTAGONIST |
| 摘要 |
The present invention relates to a novel truncated form of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF. In particular, the present invention relates to the purification, molecular cloning and recombinant expression of the truncated HGF variant. The present invention further relates to the utilization of the small HGF variants in the diagnosis and treatment of diseases in which cell proliferation is either excessive as in the case of malignancy or impaired due in part to aberrant expression of the various forms of HGF.
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| 申请公布号 |
CA2091700(C) |
申请公布日期 |
2002.11.19 |
| 申请号 |
CA19912091700 |
申请日期 |
1991.09.10 |
| 申请人 |
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发明人 |
RUBIN, JEFFREY S.;CHAN, ANDREW M.-L.;AARONSON, STUART A.;BOTTARO, DONALD P. |
| 分类号 |
C07K14/52;A61K31/7088;A61K38/00;A61K38/19;A61K39/395;A61K48/00;A61P13/08;A61P35/00;A61P43/00;C07K1/22;C07K14/00;C07K14/47;C07K14/475;C12N1/21;C12N5/10;C12N15/09;C12N15/16;C12P21/02;C12Q1/02;C12Q1/68;C12R1/91;G01N33/50;G01N33/53;(IPC1-7):C12N15/18;A61K38/18 |
主分类号 |
C07K14/52 |
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代理人 |
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