| 摘要 |
The invention relates to a YT cell line, modified by genetic engineering, into which the genes of receptors are introduced and which is suitable for treating tumours, tumour metastases, virus infections, for cleaning (purging) blood stem cell preparations and also for diagnostic purposes. Areas of application include the medical field and the pharmaceutical industry. The aim of the invention is to identify tumour cells and other target cells by means of the gene transfer of specific receptors into the YT cell line. An additional aim is to cause a lysis of the identified tumour cells and other target cells, using the newly created cell line. The inventive cell line contains one or more receptors (consisting of variable regions of tumour-specific or target cell specific antibodies (single chain Fv fragments)) and optionally a signal chain, which is derived from the zeta-chain of the human T-cell receptor. |
