发明名称 DIHYDROIMIDAZO[4,5-E]INDOLE AND 7H-PYRROLO[3,2-F]QUINOXALINEDERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGICLIGANDS
摘要 Compounds of the formula (I) in which R1, R2, R3 and R4 are as defined in Claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particula r Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia, anorexia nervosa or other eating disorders, compulsive behaviour, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence. Strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterised by an excess of circulati ng serotonin or by serotonergic hyperactivity.
申请公布号 CA2445834(A1) 申请公布日期 2002.11.07
申请号 CA20022445834 申请日期 2002.03.30
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG 发明人 SCHIEMANN, KAI;BOETTCHER, HENNING;LEIBROCK, JOACHIM
分类号 A61K31/439;A61K31/4985;A61P1/04;A61P1/08;A61P1/14;A61P3/04;A61P5/24;A61P15/00;A61P21/04;A61P25/00;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P43/00;C07D519/00;(IPC1-7):C07D519/00;C07D453/00;C07D487/00;A61K31/418;A61K31/498 主分类号 A61K31/439
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