发明名称 |
GENE THERAPY FOR TREATING OCULAR-RELATED DISORDERS |
摘要 |
The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof. |
申请公布号 |
EP1253948(A2) |
申请公布日期 |
2002.11.06 |
申请号 |
EP20010909022 |
申请日期 |
2001.02.09 |
申请人 |
GENVEC, INC. |
发明人 |
KOVESDI, IMRE;BROUGH, DOUGLAS, E.;MCVEY, DUNCAN, L.;WEI, LISA |
分类号 |
C12N15/09;A61K35/76;A61K48/00;A61P27/02;C07K14/71;C07K14/81;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|