Sulpur derivatives containing a retroamide bond as inhibitors of endothelin-converting enzymes

摘要

The following products: [S-R+, S+)] N-[1-(mercaptomethyl)-2-phenylethyl]-alpha-[[phenylmethoxy) carbonyl] amino]-1H-indole-3-propanamide, 2'-cyano-alpha-[[[1-mercaptomethyl)-2-phenylethyl] amino] carbonyl] (1,2'-biphenyl)-4-propanoic acid, (R)N-(1-mercaptomethyl)-2-phenylethyl)-11-phenoxy-undecanamide, said products being in all possible racemic, enantiomeric and diastereoisomeric forms, as well as the addition salts with pharmaceutically acceptable mineral and organic bases of said products of formula (I) having an inhibitory activity on enothelin-converting enzymes.