发明名称 |
Formation and anion-exchange of crystalline echinocandin ammonium salts |
摘要 |
A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nano-filtration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.
|
申请公布号 |
US2002161176(A1) |
申请公布日期 |
2002.10.31 |
申请号 |
US20010944309 |
申请日期 |
2001.08.30 |
申请人 |
DALDER BRIAN WESTON;DOTLICH MICHAEL ANTHONY;KALLMAN NEIL JOHN;LARSEN SAMUEL DEAN;VAN DEN BERGHE SNOREK SHARON;VICENZI JEFFREY THOMAS |
发明人 |
DALDER BRIAN WESTON;DOTLICH MICHAEL ANTHONY;KALLMAN NEIL JOHN;LARSEN SAMUEL DEAN;VAN DEN BERGHE SNOREK SHARON;VICENZI JEFFREY THOMAS |
分类号 |
A61K38/00;C07K7/56;(IPC1-7):C07K7/64 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|