Sustained release ranolazine formulations

摘要

A sustained release ranolazine formulation contains a mixture of at least 50 wt% ranolazine and a pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The pH-dependent binder inhibits the release of ranolazine from the sustained release dosage form when the sustained release dosage form is subjected to an aqueous environment having a pH of the stomach and that promotes the release of a therapeutic amount of ranolazine in an aqueous solution having ph above 4.5.