Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-phenylpiperidin-1-YL)-1-propanol and intermediates useful therefor.

摘要

The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol: The present invention is further directed to a process for the preparation of a (2S)-(+)-compound of formula (II): wherein R<1> is a protecting group. In addition, the present invention relates to intermediates useful in said processes.