Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
申请公布号
WO02083854(A2)
申请公布日期
2002.10.24
申请号
WO2002US11521
申请日期
2002.04.12
申请人
BIOGEN, INC.;LYNE, PAUL, D.;GARBER, ELLEN, A.;SALDANHA, JOSE, W.;KARPUSAS, MICHAEL
发明人
LYNE, PAUL, D.;GARBER, ELLEN, A.;SALDANHA, JOSE, W.;KARPUSAS, MICHAEL