摘要 |
<p>A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO-; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy.</p> |